FOOD SCIENCE ›› 2020, Vol. 41 ›› Issue (7): 275-282.doi: 10.7506/spkx1002-6630-20190330-392

• Reviews • Previous Articles     Next Articles

Recent Advances in Understanding the Antitumor Activity of Polysaccharides from Plants

BIAN Liang, CHEN Huaguo, ZHOU Xin   

  1. (Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine,Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China)
  • Online:2020-04-15 Published:2020-04-20

Abstract: As a class of natural products with many biological activities, plant polysaccharides have become a research hotspot in the field of anti-tumor functional foods because of their advantages of high efficiency and low toxicity. Clinical anti-tumor trials have demons plant polysaccharides can alleviate immunosuppression, enhance immune response, and inhibit the growth, invasion and metastasis of tumors.?In this review, the anti-tumor plant polysaccharides that have been reported over the decade are summarized. The anti-tumor mechanisms of plant polysaccharides are elucidated from four perspectives: regulation of tumor microenvironment, targeted cancer cell therapy, iron metabolism and erythrocyte immunity. Finally, the structure-activity relationship of anti-tumor plant polysaccharides is also discussed, and future research directions are presented in order to promote in-depth studies of plant polysaccharides and provide a theoretical basis for the research and development of anti-cancer foods.

Key words: plant polysaccharides, antitumor, mechanism

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