Preventive and Curative Effects and Mechanism of Sesamin against Nonalcoholic Fatty Liver Disease in Mice

Abstract

Abstract: In this study, the preventive and curative effect of sesamin against nonalcoholic fatty liver disease (NAFLD) in mice and its mechanism of action were investigated. NAFLD mouse models were established by feeding high fat diet. Serum lipid and free fatty acid composition, oxygen radical metabolism and liver injury were analyzed to evaluate the preventive and curative effect of sesamin against NAFLD in mice. Sesamin prevention (50 mg/(kg•d)) and treatment (50, 100 mg/(kg•d)) effectively decreased serum levels of T-CHO and TG in NAFLD mice, significantly improved serum HDL-C level, increased serum percentage of free unsaturated fatty acids and had positive regulatory effects on serum lipid levels. In addition, sesamin also could lower liver MDA level and serum levels of GOT and GPT and increase liver T-AOC level. Histopathological observation indicated that sesamin markedly alleviated liver lesions in NAFLD mice. Hence, sesamin has both preventive and curative effects against NAFLD in mice and its mechanism of action is relevant to lowering serum lipid levels, regulating serum free fatty acid composition (elevating unsaturated fatty acid proportion), antioxidation and attenuating hepatocyte damage.

Key words: sesamin, nonalcoholic fatty liver disease (NAFLD), serum lipid, antioxidation, hepatocyte damage

CLC Number:

TS229

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Preventive and Curative Effects and Mechanism of Sesamin against Nonalcoholic Fatty Liver Disease in Mice

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