Effect of (－)-Epigallocatechin Gallate on Cancer Cell Signal Transduction Chain

Abstract

Abstract: EGCG is not only an important active component in tea extract, but also one of the most potential chemopreventive agents. EGCG has obvious impacts on a variety of signaling pathways in cancer cells, thus leading to the inhibition of cancer cell proliferation, accelerating apoptosis and suppressing cell migration and invasion. Current research is focused on MAPK, PI3K-Akt, NF-κB and other signaling pathways. In this paper, the effect of EGCG on different signal transduction chains is summarized.

Key words: EGCG, signal transduction, MAPK, PI3K-Akt

CLC Number:

References

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