Abstract: An analytical method using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) was established for determining multi-elements (Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Cd, Sn, Hg and Pb) in red wine. Samples were filtered through a 0.45 μm pore size cellulose filter, and after acidification with nitric acid, the filtrate was directly analyzed. Instrumental parameters were optimized so that elimination of inferences was achieved via mass-shift reaction of different reaction gases. The limits of detection (LOD) were in the range of 1.4–51.8 ng/L for all analytes. The recoveries for spiked samples were in the range of 94.0%–104.7%, with relative standard deviations (RSDs) no more than 4.0%. The method is simple and fast with low detection limit, good accuracy and high precision, making it suitable for the determination of multi-elements in red wine.

Key words: red wine, inductively coupled plasma tandem mass spectrometry, multi-element, mass spectral interferences, mass-shift reaction