纤溶化合物促进血栓溶解作用的初步研究

食品科学 ›› 2007, Vol. 28 ›› Issue (8): 471-475.

纤溶化合物促进血栓溶解作用的初步研究

姝亚, 吴文惠, 汪之和, 陆魏, 包斌

上海水产大学食品学院；上海水产大学食品学院上海200090；上海200090；

出版日期:2007-08-15 发布日期:2011-10-24

Primary Study on Fibrinolytic Compound Promoting Fibrinolysis in vivo

SHU Ya, WU Wen-Hui, WANG Zhi-He, LU Wei, BAO Bin

College of Food Science and Technology, Shanghai Fisheries University, Shanghai 200090, China

Online:2007-08-15 Published:2011-10-24

摘要/Abstract

摘要： 利用FITC标记纤维蛋白建立肺血栓模型,将纤溶促进化合物GDG从尾静脉投与肺血栓大白鼠,按时检测血浆中荧光强度的变化。首次发现了GDG促进实验动物血栓溶解作用,推测GDG的添加使FITC-肺血栓动物模型尿激酶型纤溶酶原激活剂前体的内因性活性提高。

关键词: GDG, 肺栓塞动物模型, 荧光物质, 纤溶作用

Abstract: The effects of GDG on clotlysis induced and its possible mechanism were investigated with GDG as a promoting fibrinolytic compounds injected in the tail vein of rats and pulmonary thrombotic model on rats established by marking fibrin with FITC. Fluorescence in various groups was assayed. It was found firstly that GDG has the effect of promoting fibrinolysis. It was speculated that GDG could enhance intrinsic activity of prourokinase as a plasminogen activator for FITC-labeling pulmonary thrombotic rats.

Key words: GDG, pulmonary thrombotic model, fluorescent material, fibrinolysis

姝亚, 吴文惠, 汪之和, 陆魏, 包斌. 纤溶化合物促进血栓溶解作用的初步研究[J]. 食品科学, 2007, 28(8): 471-475.

SHU Ya, WU Wen-Hui, WANG Zhi-He, LU Wei, BAO Bin. Primary Study on Fibrinolytic Compound Promoting Fibrinolysis in vivo[J]. FOOD SCIENCE, 2007, 28(8): 471-475.