食品科学 ›› 2021, Vol. 42 ›› Issue (18): 7-14.doi: 10.7506/spkx1002-6630-20200910-127

• 食品化学 • 上一篇    下一篇

装载α-生育酚的乳木果油固体脂质纳米颗粒的制备与表征

杨振,李曼,慕鸿雁,熊柳,孙庆杰   

  1. (青岛农业大学食品科学与工程学院,山东 青岛 266000)
  • 发布日期:2021-09-29
  • 基金资助:
    国家自然科学基金面上项目(31671814);山东省泰山学者项目(t401712058)

Preparation and Evaluation of Shea Butter Solid Lipid Nanoparticles Loaded with α-Tocopherol

YANG Zhen, LI Man, MU Hongyan, XIONG Liu, SUN Qingjie   

  1. (College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266000, China)
  • Published:2021-09-29

摘要: 以吐温20和吐温80为乳化剂,天然的固体脂质乳木果油为脂质基质,通过高速剪切均质制备乳木果油固体脂质纳米颗粒(solid lipid nanoparticle,SLN)。乳木果油SLN冷却固化温度为4 ℃;当油水比例为5∶5~1∶9时,动态光散射仪测定乳木果油SLN粒径范围为30.43~278.13 nm,透射电镜观察发现,乳木果油SLN形态为球形。差示扫描量热仪测定结果显示,乳木果油SLN热峰值温度范围为19.05~28.96 ℃,低于乳木果油的热峰值温度(35.84 ℃)。而且,以乳木果油SLN为载体包埋亲脂性活性物质α-生育酚,包埋率高达95.11%,因此,将乳木果油SLN用作脂溶性活性物质的载体具有较大的应用潜力。

关键词: 均质;乳液;包埋率;载体

Abstract: In this study, we fabricated shea butter solid lipid nanoparticles (SLNs) by a high-speed shear homogenization method with Tween 20 or Tween 80 as the emulsifier. SLNs were obtained by cooling down to 4 ℃. The particle size range of SLNs with oil to water ratio of 5:5 to 1:9, as determined by dynamic light scattering, was 30.43–278.13 nm. The transmission electron microscopic (TEM) images showed that the particle morphology was spherical. The thermal peak temperature of SLNs ranged from 19.05 to 28.96 ℃ as measured by a differential scanning calorimeter, which was lower than that of shea butter (35.84 ℃). In addition, α-tocopherol, a lipophilic bioactive ingredient, was loaded into SLNs with encapsulation efficiency as high as 95.11%. Therefore, SLNs has great potential for application as a carrier for liposoluble bioactive materials.

Key words: homogenization; emulsion; encapsulation efficiency; carrier

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