食品科学 ›› 2025, Vol. 46 ›› Issue (24): 352-360.doi: 10.7506/spkx1002-6630-20250714-114

• 专题论述 • 上一篇    

β-葡聚糖调节肠道菌群健康效应机制及构效关系研究进展

刘懿航,耿洁,刘利平,冯杰,张劲松,刘艳芳   

  1. (1.上海市农业科学院食用菌研究所,农业农村部南方食用菌资源利用重点实验室,国家食用菌工程技术研究中心,国家食用菌加工技术研发分中心,上海市农业遗传育种重点实验室,上海 201403;2.上海海洋大学食品学院,上海 201306)
  • 发布日期:2025-12-26
  • 基金资助:
    国家现代农业产业技术体系项目(CARS-20);上海市农业科学院卓越团队建设计划项目(2022A-03)

Research Progress on the Mechanism and Structure-Activity Relationship of β-Glucans in Regulating the Health Effects of Gut Microbiota

LIU Yihang, GENG Jie, LIU Liping, FENG Jie, ZHANG Jinsong, LIU Yanfang   

  1. (1. Key Laboratory of Agricultural Genetics and Breeding of Shanghai, National R&D Center for Edible Fungal Processing, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; 2. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China)
  • Published:2025-12-26

摘要: β-葡聚糖来源广泛,是目前研究较为深入的一种膳食多糖。β-葡聚糖不被口腔、胃肠道消化,可以到达结肠并被肠道菌群发酵利用,产生有益于人体健康的代谢产物,具有良好的益生元特性。本文综述了β-葡聚糖的不同来源与结构,β-葡聚糖调节肠道及对机体健康的功能机制,总结了不同结构β-葡聚糖与其益生活性间的构效关系,旨在为β-葡聚糖的开发应用提供理论依据。

关键词: β-葡聚糖;肠道菌群;益生活性;构效关系

Abstract: β-Glucans, dietary polysaccharides coming from a wide variety of sources, have been researched intensively. Being resistant to oral and gastrointestinal digestion, β-glucans can reach the colon where they are fermented by the gut microbiota, generating health-benefiting metabolites and demonstrating excellent prebiotic properties. This article reviews the diverse sources and structures of β-glucans, elucidates their functional mechanisms in regulating gut and systemic health, and summarizes the structure-activity relationship of β-glucans as prebiotics. The review aims to provide a theoretical foundation for the application of β-glucans.

Key words: β-glucans; gut microbiota; prebiotic activity; structure-activity relationship

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