父源性环境内分泌干扰物的代际表观遗传调控：孕前暴露对子代健康研究进展

摘要/Abstract

摘要： 环境内分泌干扰物（Endocrine Disrupting Chemicals, EDCs）广泛存在于工业化和现代化环境中，主要通过食物链生物富集和食品包装材料的迁移进入人体，对食品安全和人类健康构成潜在风险。EDCs对生殖细胞具有显著毒性且可诱导表观遗传改变，已成为跨代健康风险的重要因素。然而，与母体暴露相比，父源性EDCs暴露的代际效应至今研究仍较少。本综述聚焦父代孕前EDCs暴露，总结其雄性生殖毒性及子代健康的影响，重点探讨其表观遗传机制，旨在为完善雄性生殖毒性风险评估提供依据，并为开发靶向表观遗传干预策略提供方向。

关键词: 父系遗传, 环境内分泌干扰物, 代际效应, 跨代效应, 表观遗传学

Abstract: Environmental endocrine disruptors (EDCs) are widely present in industrialized and modern environments. They primarily enter the human body through bioaccumulation in the food chain and migration from food packaging materials, posing potential risks to food safety and human health. EDCs exhibit significant toxicity to germ cells and can induce epigenetic alterations, making them a critical factor in intergenerational health risks. However, compared to maternal exposure, the intergenerational effects of paternal EDCs exposure remain understudied. This review focuses on paternal preconception EDC exposure, summarizes its impacts on male reproductive toxicity and offspring health, and highlights the underlying epigenetic mechanisms. It aims to provide a basis for improving risk assessment of male reproductive toxicity and to offer directions for developing targeted epigenetic intervention strategies.

Key words: paternal inheritance, environmental endocrine disruptors, intergenerational effects, transgenerational effects, epigenetics

中图分类号:

TS201.4

邸倩南李文清陶政慧朱亦淳赵晓蕾丁馨馨杨欢李雪玲. 父源性环境内分泌干扰物的代际表观遗传调控：孕前暴露对子代健康研究进展[J]. 食品科学.

倩南 rico Wenqing Li H Li H Li Xiujuan Zhou. Paternal Endocrine Disrupting Chemicals and Transgenerational Epigenetic Regulation: Research Progress on the Effects of Preconception Exposure on Offspring Health[J]. FOOD SCIENCE.

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