本实验探讨了一款普洱熟茶对糖脂代谢异常人群的健康改善作用。该茶为云南中茶茶业有限公司的上市产品Y562普洱熟茶，招募合格试饮志愿者，采用营养流行病学临床干预研究设计，试饮该茶3 个月，通过检测及对比志愿者试饮前后的人体成分（体质量、身体质量指数、体脂比、内脏脂肪）、身体围度（腰围、臀围、颈围）、糖代谢相关指标（空腹血糖、胰岛素、C肽、糖化血红蛋白）、脂代谢相关指标（总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A1和B）、血尿酸、肝脏脂肪量和肠道菌群等各项指标，探讨该普洱熟茶的健康功效。结果显示，试饮Y562普洱熟茶3 个月后，饮食和运动不变的情况下，志愿者的体质量、身体质量指数、身体围度（腰围、臀围、颈围）、血脂（高密度脂蛋白胆固醇、载脂蛋白A1和B）和肝脏脂肪量均显著改善（P＜0.05）；血糖（空腹血糖、胰岛素、C肽、胰岛素抵抗、糖化血红蛋白）、血甘油三酯、血尿酸均有改善，但差异没有统计学意义（P＞0.05）；肠道菌群改善，均匀性增加，Lactobacillus、Clostridium、Akkermansia muciniphila、Clostridium scindens、Streptococcus thermophilus等菌属/种相对丰度升高，Streptococcus、Lactococcus、Bacteroides、Bifidobacterium、Parabacteroides distasonis等菌属/种相对丰度降低。研究提示Y562普洱熟茶具有辅助减肥、改善体型、降血糖、降血脂、改善非酒精性脂肪肝的作用，预测内在机制可能与普洱熟茶调节肠道微生态及胆汁酸通路相关。

This study explored the effect of commercial ripened Pu-erh tea (Y562, China Tea (Yunnan) Industry Co. Ltd.) on improving the health of populations with abnormal glucose and lipid metabolism. Qualified volunteers were recruited for nutritional epidemiological and clinical intervention studies. The volunteers were asked to drink the tea for three months. Their body composition (body mass, body mass index (BMI), body fat ratio and visceral fat), body circumferences (waist circumference, hip circumference and neck circumference), glucose metabolism-related indicators (fasting blood glucose, insulin, C-peptide, glycosylated hemoglobin), lipid metabolism-related indicators (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1 and B), blood uric acid levels, liver fat contents, and gut microbiota were tested and compared before and after drinking the tea to explore its health benefits. The results showed that after drinking Y562 without any change in diet or exercise for three months, the body mass, BMI, body circumferences, blood lipids (high-density lipoprotein cholesterol, apolipoprotein A1 and B), and liver fat contents of the volunteers were significantly improved (P < 0.05). Blood glucose (fasting blood glucose, insulin, C-peptide, insulin resistance, and glycosylated hemoglobin), triglyceride, and uric acid levels were also improved, but without any statistical significance (P > 0.05). Moreover, the gut microbiota was improved, showing increased uniformity. The relative abundance of Lactobacillus, Clostridium, Akkermansia muciniphila, Clostridium screenens and Streptococcus thermophilus was increased, while that of Streptococcus, Lactococcus, Bacteroides, Bifidobacterium and Paraacteroides distasonis was decreased. This study suggests that ripened Pu-erh tea Y562 has the potential to help reduce the body mass, improve the body shape, reduce blood glucose and lipids, and alleviate non-alcoholic fatty liver disease (NAFLD). The underlying mechanism may be related to the regulation of the intestinal microecology and the bile acid pathways by Pu-erh tea.