Comparisons on Antioxidant and Anti-tumor Activity of Ethanol Extracts from 20 Polypores Fungi in vitro

doi:10.7506/spkx1002-6630-201105006

FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (5 ): 27-31.doi: 10.7506/spkx1002-6630-201105006

• Basic Research • Previous Articles Next Articles

Comparisons on Antioxidant and Anti-tumor Activity of Ethanol Extracts from 20 Polypores Fungi in vitro

CHEN Yong-qiang，CHEN Xian-hui，SUN Yong，MIAO Qian，WANG Li，JIANG Ji-hong*

Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province, Xuzhou Normal University, Xuzhou 221116, China

Received:2010-06-17 Revised:2011-01-19 Online:2011-03-15 Published:2011-03-03
Contact: JIANG Ji-hong E-mail:jhjiang@xznu.edu.cn

Abstract

Abstract: The antioxidant activities of ethanol extracts from the mycelia and fruit bodies of twenty polypores fungi were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method. Meanwhile, these extracts were tested for their anti-tumor activities by Alamar Blue method. The results showed that the DPPH free radical scavenging and anti-tumor activities of the extracts from fruit bodies of each of these fungi were significantly higher than those of the extracts from mycelia. A DPPH radical scavenging rate of 70% was observed for the ethanol extract of fruit body at a concentration of 5 mg/mL, and the inhibition rates of the ethanol extract against two cancer cell lines such as non-small lung cancer cell NCI-H460 and human hepatoma cell HepG2 were both around 90% at 500 μg/mL. In addition, compared with the normal cell lines, a slightly low inhibition rate of the ethanol extract on drug-resistant cells such as Bel-7402/5-Fu was also observed.

Key words: polypores, antioxidation, DPPH free radical, anti-tumor activity

CLC Number:

TS201.2

CHEN Yong-qiang，CHEN Xian-hui，SUN Yong，MIAO Qian，WANG Li，JIANG Ji-hong*. Comparisons on Antioxidant and Anti-tumor Activity of Ethanol Extracts from 20 Polypores Fungi in vitro[J]. FOOD SCIENCE, 2011, 32(5 ): 27-31 https://doi.org/10.7506/spkx1002-6630-201105006

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Comparisons on Antioxidant and Anti-tumor Activity of Ethanol Extracts from 20 Polypores Fungi in vitro

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