FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (3): 246-249.doi: 10.7506/spkx1002-6300-201003057

• Nutrition & Hygiene • Previous Articles     Next Articles

Effect of Soluble Polysaccharide PGEB-3-H from Gastrodia elata Blume on Scopolamine-induced Learning and Memory Disorders in Mice

MING Jian1,2，ZENG Kai-fang1,2，WU Su-rui4，FU Ai-ling3，ZHAO Guo-hua1,2，GUI Ming-ying4，CHEN Zong-dao1,2,*   

  1. 1. College of Food Science, Southwest University, Chongqing 400715, China；2. Chongqing Special Food Programme and
    Technology Research Center, Chongqing 400715, China；3. College of Pharmaceutical Sciences, Southwest University, Chongqing
    400715, China；4. Kunming Research Insitute of Edible Mushroom, Kunming 650223, China
  • Received:2009-05-21 Online:2010-02-01 Published:2010-12-29
  • Contact: MING Jian E-mail:mingjian1972@163.com

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Abstract:

Objective: To investigate the effect of PGEB-3-H, a soluble polysaccharide from Gastrodia elata Blume, on scopolamine-induced learning and memory disorders in mice. Methods: Learning and memory ability in mice were evaluated by Morris water maze. Acetylcholine and malondialdehyde (MDA) content were measured in brain tissues of mice. Results: Compared with model group, the time for passing water maze of mice treated with PGEB-3-H at doses of 100, 200 mg/kg bw·d and 400 mg/kg bw·d (namely, PGEB-3-H low-, medium- and high-dose groups, respectively) was obviously shorter in a dosedependent mode, and there was an extremely significant difference between PGEB-3-H high-dose group and model group (P ＜0.01). Moreover, PGEB-3-H high-dose group exhibited higher acetylcholine content in brain tissues when compared to normal saline group or positive control group. In addition, MDA content in brain tissues of PGEB-3-H medium-dose group exhibited a significant decrease (P ＜0.05). Conclusion: PGEB-3-H can improve scopolamine-induced learning and memory disorders in mice, and its mechanism may be due to the increase of acetylcholine content in brain tissues.

Key words: Gastrodia elata Blume, polysaccharide, scopolamine, learning and memory, Morris water maze, acetylcholine

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