Abstract:

A gas chromatograph-mass spectrometric (GC-MS) method was developed for the rapid determination of sodium cyclamate in foodstuffs. Samples were extracted with hexane in an ultrasonic field, and the extracts were analyzed by GC-MS after derivatization with a mixture of 50 g/L sodium nitrite solution and 100 g/L sulfuric acid (5:5, V/V). The detection limit was 40 mg/kg (signal/noise ratio = 3.0). The recoveries for cyclamate in six spiked samples ranged from 88.0 % to 108.0% and the relative standard deviations (RSDs) were less than 7.16%. This method has obvious advantages such as high sensitivity, specificity and simplicity versus other methods reported previously, therefore can be used to detect effectively low-level sodium cyclamate in foods

Key words: gas chromatography-mass spectrometry (GC-MS), sodium cyclamate, foodstuff