Abstract: In this study, the effect of phytosterol ester at different dosages on serum lipid level of hyperlipidemic mice was investigated. A hyperlipidemic mouse model was established by feeding high fat diet, and then the mice were administered with phytosterol ester at the dosages of 50, 75, 100, 125 mg/(kg·d) and 150 mg/(kg·d), respectively. The results showed that phytosterol ester could significantly reduce total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and arteriosclerosis index (AI) through increasing HDL-C/LDL-C and HDL-C/TC index when compared with hyperlipidemic group. However, no significant effect of phytosterol ester on triglyceride (TG) level was observed. In addition, phytosterol ester could regulate serum lipid level at the dose of 75 mg/(kg·d)  for phytosterol ester (P＜0.05).

Key words: phytosterol ester, mice, hyperlipidemia, hypolipidemia