Abstract: Objective:To study the effects of Lycium ruthenicum pigment(PLR)on blood lipids level and lipid peroxidation in mice with hyperlipemia.Method:Male ICR mice were randomly divided into 6 group according to body weight and serum cholesterol levels.They were fed a normal diets(NG),a high fat supplemented diets(HF),and a high fat supplemented diets with Simvastain(HF+S),a high fat supplemented diets with 100,200,400 mg/kg(HF+PLR100,200,400)respectively.After 6 weeks,serum TC,TG,HDL-C,LDL-C and organism T-AOC,SOD,GSH-PX,MDA were determined respectively.Results:Compared with HF model group,PLR could reduce the serum TC,TG,LDL-C concentration,increase serum and liver T-AOC,GSH-PX activities,and decrease liver MDA content significantly(p<0.05).The serum HDL-C content and serum,liver SOD and activities were not affected significantly(p>0.05).Results:PLR can inhibite the increase of blood lipids level and increase antioxidant activity in mice with hyperlipemia.

Key words: Lycium ruthenicum Murr., pigment, hyperlipemia, lipid peroxidation