Abstract: Objective: To discuss the immunoloregulation and protection mechanism of Se-enriched Lactobacillus on induced- CCl 4 liver injury rats. Eighty healthy SD rats with half of female and male were chosen and randomly divided into a control group (group C), a group CCl 4 , a CCl 4 plus low dose Se-enriched lactobacillus group (group CCl 4 -LSe) and a CCl 4 plus high dose Se- enriched lactobacillus group (group CCl 4 -HSe). The liver injury was induced by abdominal injection of CCl 4 (0.1ml/100g body weight) on every other day over four weeks. Results: During the entire experimental period, Se-enriched Lactobacillus was capable to increase significantly GSH-Px activity in liver damage tissue homogenate of rats; Liver homogenate MDA content increased significantly in group CCl 4 , but MDA levels of groups CCl 4 -LSe and CCl 4 -HSe were close to those of group C; RBC-CR 1 rosette rates(%) of groups CCl 4 -LSe and CCl 4 -HSe were higher or significantly superior to those of group CCl 4 RBC-IC rosette rates(%) of group CCl 4 increased significantly. However, groups CCl 4 -LSe and CCl 4 -HSe were close to group C and markedly lower than group CCl 4 T-lymphocytes(%) of groups CCl 4 -LSe and CCl 4 -HSe had no significant differences as compared with group C, but a significant decrease was observed in group CCl 4 , and B-lymphocytes(%) had sentrary changes; Spleen and blood NK cell activities were significantly lower in group CCl 4 than in group C, and higher in groups CCl 4 -LSe and CCl 4 -HSe also higher than in group CCl 4 . Conclusions: Se-enriched lactobacillus could intervene the lipid peroxidation reaction of liver injury induced by CCl 4 , and ameliorate and enhance immunologic cell function activity to keep its normal and beneficial action through anti-damage protection.

Key words: Se-enriched lactobacillus, rat, liver injury, immunological cell