Abstract: Objective: To investigate the effect of exercise and puererin on antioxidant capacities of diabetic rats serum. Methods: Adult male streptozotocin-diabetic rats were used as research object. For exercise, puererin supplement and exercise combined with puererin supplement, the changes in T-AOC, CAT, GSH-PX, CAT activity, GSH, MDA contents, blood glucose and insulin were measured. Results: The levels of T-AOC, CAT, GSH-PX, CAT activity and insulin of treated diabetic groups are significantly higher (p<0.05), while MDA contents and blood glucose concentration are very lower (p<0.01) than untreated diabetic group. Similarly, the significant difference also exists between exercise combined with puererin supplement group and exercise group or puererin supplement group (p<0.05). Conclusion: Exercise and puererin can enhance serum antioxidant capacities of diabetic rats, reduce lipid peroxidative damage and improve level of blood glucose and insulin. Exercise combined with puererin supplement shows the best effect among all experimental groups. The combination of exercise with puerarin supplement would perform a satisfactory healing for diabetes.

Key words: exercise, puerarin, diabetic rats, antioxidant capacity