FOOD SCIENCE ›› 2008, Vol. 29 ›› Issue (9): 575-579.

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Study on Therapeutic Effect of Chicory Polysaccharides on Fatty Liver Function of Rat

 ZHENG  Hong-Yan, CHANG  You-Quan, CAO  Bai-Ying, QI  Ying-Xin   

  1. 1.College of Food Science and Engineering,Jilin Agricultural University,Changchun 130118,China;2.Biology Mobile Post- doctorate Research Stations of Northeast Normal University,Changchun 130024,China;3.College of Biology and Food Engineering,Jilin Teacher’Institute of Engineering and Techology,Changchun 130052,China
  • Online:2008-09-15 Published:2011-12-08

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Abstract:  Objective:To observe the therapeutic effect of chicory polysaccharides (CPS) on fatty-liver and investigate its pharmacodynamics. Methods: High fatty diet and white wine perfusate were used to establish the fatty liver model of rat for 8 weeks.Compared with Dongbao Gantai as the control medicine, fatty liver rats were treated by CPS for 4 weeks and contents of TC and TG, activities of ALT, AST, ALP and GGT, contents of Liver-TG and TC, and activities of DTD, SOD and MDA were determined.Conclusion: It was found that the pharmacodynamics and therapeutic function of CPS to fatty liver are: adjusting lipometabolism, reducing TG and TC; decreasing fatty degeneration of liver cell; promoting convalescence of hepatocellular function; and anti-lipid peroxidation increasing the activity of peroxidase and decreasing the content of lipid peroxidation products.

Key words: fatty liver(FL), chicory polysaccharides (CPS), Kupffer cell, fluidity of cell membrane