FOOD SCIENCE ›› 2004, Vol. 25 ›› Issue (10): 305-308.

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Influence of Stigma Maydis Polysaccharide (SMPS) on CCl4-hepatotoxity in Mice

 CHANG  You-Quan, WANG  Wei-Jia, YANG  Shi-Jie, CAO  Shu-Gui, MA  Jin-Rong, CHANG  Xi-Tao   

  1. 1.Key Laboratory for Molecular Enzymology and Engineering of Ministry of Educational Jilin University;2.The Pharmacology of Basic Medical School of Jilin University;3.Central Hospital in Baicheng of Jilin Province
  • Online:2004-10-15 Published:2011-10-24

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Abstract: Objective: To study the protective function of Gardeniayellow(SMPS) against CCl4-induced hepatotoxicity in mice.Methods: Healthy Kunming male mice, weighting (20±2)g, 50 ones were randomized into 5 groups with 10 per-group .control group, CCl4-injured group, low dose group (CCl4 injured+0.1ml SMPSsolution), medium dose group(CCl4-injured+0.2mlSMPS solution) and high dose group(CCl4-injured+0.4mlSMPS solution). SMPS solution was given i.g.5d prior to CCl4 injury.Glutamate-pyruvate transaminase (SGPT), glutamic-oxaloacetic transaminase (SGOT) and lacticde hydrogenase(LDH) activi-ties in serum were determined 18h after CCl4-injury. Hepaticmalondialdehyde (MDA), glutathione (GSH) and liver index werealso detected. Results: In SMPS treated groups, the increases of SGOT, SGPT and LDH activities in serum were inhibitedobviously. The decreases of liver GSH were reversed actually. The elevations of MDA and liver index were prevented significantly.The lesions in liver lobule were ameliorated obviously. Conclusion: Gardeniay ellow canpro-tectagainst CCl4-inducedhepatotoxicity.

Key words: Stigma maydis Polysaccharide(SMPS), carbon tetrachloride(CCl4), hepatotoxicity