Abstract: The extraction technology and antioxidant activity of lignans in sesame cake were studied. Solid-liquid ratio, extraction time, temperature, times were selected as four factors to design the orthogonal test, and the optimum conditions of extraction were obtained. The results showed that the optimum conditions for the extraction are as follows: Solid-liquid ratio 1:6, extraction time 10h, temperature 55℃ and times 3. The crude extract rate was accounted for 2.62%. The antilipid-peroxidationof the extract on liver was assayed by the determination of malondialdehyde(MDA) with TBA spectrometric method. The results showed that the extract of sesame cake can inhibit the lipidperoxidation of liver and the lipidperoxidation of mitochondria can be induced by Fe2+-VC.

Key words: sesame, cake, extract, antioxidant activity