Abstract: The parameters of preparing hydroxypropyl-β-cyclodextrin were optimized. The ranges of reaction temperature, reaction time and dialysis time were confirmed through single factor experiment, then a response surface method was conducted to get the following optimal parameters: reaction time 16.05h, reaction temperature 31.06℃ and dialysis time 7.41h. The degree of substitution (DS) and recovery prepared under optimal parameters respectively are 4.10 and 61.80%.

Key words: hydroxypropyl-&beta, -cyclodextrin； response surface method； optimization；