Abstract: It was to elucidate parts of possible mechanismof catechin in the rapeutic nephritic syndrome and to preventchronic renalprogressive i njury by investgating catechin effe ct onnitric oxide(NO)contentinplasma and renal cortex in this experiment.30f emale SDrats were randomly divided i nto six groups as control,nephritic,dexamethasone -treated,catechin -prevented,catechin -treated and dexamethasone associated catechin -tredted.Intheendofexperiment,th eexcretionof 24hurinaryprotein,a ndthenitricoxied(NO)concentrationsin plasmaandrenalcortexbymeans ofbi ochemistryassay were tested.Asemi quantitativescore was usedto evalu ate the injury degree on glomerular and t ubulointerstitium.The results ind icated that the therapeutic way of dexam-ethasone +catechin -treated was the best.And the catechin intake could s low down the chronic progressive kidney lesions through increasing r enal cortex and plasma NOconcentrations and decreasing the excretion of24h urinary protein.

Key words: catechin, nephrotic syndrome, nitr ic oxide, patholic