Abstract:

The synthesis catalyzed by immobilized lipase (Novozym®435) of L-ascorbyl myristate in ultrasonic field was
studied. The dissolution rate of the reactants could be accelerated greatly by using ultrasonic, and the reaction time could be
reduced from 48 h to 4h. The productivity reached 77.58%, and the purity of purified products was 98.1%. The immobilized
lipase could be reused 4 times in ultrasonic field. L-ascorbyl myristate showed strong antioxidant activity similar to that
of L-ascorbyl palmitate and superior to that of tertiary butylhydroquinone (TBHQ) at an equal concentration as indicated
by hydroxyl radical and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacities and reducing power. The
antioxidant activity of L-ascorbyl myristate was still strong even when added to oils.

Key words: ultrasound, lipase-catalyzed synthesis, L-ascorbyl myristate, antioxidant activity