Abstract:

In order to provide safety guarantee for its development and application, the acute toxicity and mutagenicity of
corn germ antioxidant peptide (CGAP) in mice were evaluated by testing maximum tolerable dose (MTD), and mutagenicity
of CGAP was studied by sperm abnormality test, bone marrow cell micronucleus test and Ames test. The results showed that
MTD of CGAP was larger than 34 g/kg in mice and all the results of mutagenicity tests obtained were negative. Thus, CGAP
does not show any acute toxicity or mutagenicity.

Key words: corn germ antioxidant peptide, sperm abnormality, bone marrow cell micronucleus, Salmonella typhimurium reverse mutation test (Ames test)