Recent Progress in Research Antitumor Activity of Plant Polyphenols by Wnt/β-catenin Signaling Pathway

doi:10.7506/spkx1002-6630-201505042

Abstract

Abstract:

Wnt signal transduction pathway, which is closely related to normal embryonic development, and cell survival,
growth, proliferation and differentiation, could deliver the information associated with growth and development. Its
aberrant activation or inhibition plays important roles in the development of cancers. While plant polyphenols are becoming
important sources of chemopreventive agents because of their antitumor potential. This review describes the relationships
between Wnt/β-catenin signaling pathway components and regulation mechanisms and tumors as well as the targets and
mechanisms by which the plant polyphenols act on Wnt signaling pathway in cancer progression. We hope that this paper
can provide some evidence for developing health-promoting foods or drugs containing plant polyphenols.

Key words: plant polyphenols, Wnt/β-catenin, signaling pathway, antitumor activity

CLC Number:

R282.7

ZHANG Xiaoli1, WANG Huiqing1, ZHANG Yueqiao1, LU Keke1, MING Jian1,2,3,*. Recent Progress in Research Antitumor Activity of Plant Polyphenols by Wnt/β-catenin Signaling Pathway[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201505042.

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Recent Progress in Research Antitumor Activity of Plant Polyphenols by Wnt/β-catenin Signaling Pathway

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