Abstract:

The enrichment of 758.6 μg/g selenium in Spirulina platensis was obtained by adding Na2SeO4 into Zarrouk
culture medium. Selenium-enriched Spirulina platensis was detected using quantum resonance spectrometer (QRS) to
analyze the major amino acids, vitamins, and measures of anticancer capacity, immune benefits and antihyperlipidemic
activity. The values of these parameters in selenium-enriched Spirulina platensis were higher than in the normal one. In
order to explore the effects of selenium-enriched Spirulina platensis on serum lipid levels of acute hyperlipidemic mice, we
established acute hyperlipidimic mouse model by single intravenous injection of 400 mg/kg Triton WR-1339 after the mice
were gavaged with selenium-enriched Spirulina platensis for two weeks. At 18 h after the injection, the mice were killed
and blood samples were collected for analysis. The results showed that the serum levels of TG, TC and LDL-C in mice
given high dose of selenium-enriched Spirulina platensis were significantly reduced whereas HDL-C concentration was
significantly increased compared with the model control group (P < 0.01). In the high-dose group, serum TG and LDL-C
values were also significantly reduced and HDL-C concentration was increased compared with the ordinary Spirulina
platensis group (P < 0.05). The above results indicate that Se-enriched Spirulina platensis gavaged to acute hyperlipidemic
mice has a significant hypolipidemic effect.

Key words: selenium-enriched Spirulina platensis, quantum resonance, acute hyperlipidemia