Simultaneous Determination of Fluoroquinolone Residues in Honey and Royal Jelly by QuEChERS and High Performance Liquid Chromatography-Tandem Mass Spectrometry

doi:10.7506/spkx1002-6630-201616039

Abstract

Abstract:

A multi-residue analytical method for the determination of 14 fluoroquinolone residues in honey and royal
jelly using QuEChERS extraction coupled with high performance liquid chromatography-tandem mass spectrometry
(HPLC-MS/MS) was developed. Samples were extracted with acetonitrile containing 1% acetic acid, cleaned up by
dispersive solid phase extraction with C18-EC and PSA as absorbent. Recoveries from samples spiked at three levels were
between 80.4% and 110.2% with relative standard deviations (RSDs) lower than 16.3%. The limits of detection (LODs) and
limits of quantification (LOQs) for honey were 0.45-2.58 ng/g and 1.51-8.59 ng/g, respectively. For royal jelly, the LODs
and LOQs were 0.51-3.22 ng/g and 1.69-10.75 ng/g, respectively. The established method could meet the requirement for
the determination of fluoroquinolone residues in honey and royal jelly samples.

Key words: honey, royal jelly, QuEChERS, HPLC-MS/MS, fluoroquinolone residues

CLC Number:

O651

ZHANG Zhongyin, ZHAO Liuwei, CAO Weirui, ZHOU Jinhui. Simultaneous Determination of Fluoroquinolone Residues in Honey and Royal Jelly by QuEChERS and High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201616039.

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Simultaneous Determination of Fluoroquinolone Residues in Honey and Royal Jelly by QuEChERS and High Performance Liquid Chromatography-Tandem Mass Spectrometry

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