Abstract: Three classes of chalcone derivatives including three dichalcones, one flavonol compound containing chalcone
structure and four flavone compounds containing chalcone structure were synthesized from chalcone by condensation
reactions. These new compounds were characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR),
mass spectrometry (MS) and elementary analysis (EA). Their scavenging effects on superoxide radical (O2-·), hydroxyl
radical (·OH), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and their total reducing capacities were measured and
compared. The antioxidant protection of some compounds with higher free radical scavenging capacity on edible oils was
also studied. The results showed that most of the chalcone derivative compounds at the concentration of 0.5 mg/mL had
significant scavenging effects on all the tested free radicals and that among these derivatives, the dichalcone compound 2 had
stronger antioxidant effect on edible oils than VC.

Key words: derivatives of chalcones, synthesis, antioxidant activity