Abstract: In order to explore the migration of biphenol A from polycarbonate milk bottles to foods, polycarbonate milk bottles were soaked in four food simulants such as distilled water, 3% acetic acid solution, 15% ethanol solution and olive oil for 3 days and the content change of biphenol A in the food simulants after 1, 2 and 3 days of soaking was detected by high performance liquid chromatography using an external standard method. The recovery rate, accuracy and linear relationship of the developed method were studied. At 0.1, 1 and 10 μg/mL spike levels, the recovery rates were 77.0%－98.7% with a variant coefficiant of 5%－9.8%. A good linear relationship was observed over the range of 0.1 to 10 μg/mL with a correlation coefficient of 0.99996. This method has been satisfactorily used to determine migration rates of biphenol A from polycarbonate milk bottles to different mimic foods at different contact peroids.

Key words: polycarbonate, milk bottle, biphenol A, high performance liquid chromatograph (HPLC), food simulants, migration rule