Abstract: Protein ubiquitination, an important post-translational modification, plays a wide role in the life activities of eukaryotic cells. E3 ubiquitin ligases specifically recognize target proteins in the ubiquitin-proteasome degradation system and play a decisive role in the ubiquitination pathway. Recent studies have shown that E3 ubiquitin ligases play an extensive regulatory role in the growth, development and stress response of fruits and vegetables. This article introduces the ubiquitin system and the types of E3 ubiquitin ligase in fruit and vegetable crops, focusing on recent advances in understanding the regulatory role and mechanisms of E3 ubiquitin ligases in the growth, development, and stress response of fruits and vegetables. We anticipate that this review will provide a reference for research on the regulatory role of E3 ubiquitin ligases in the life activities of fruits and vegetables.

Key words: fruits and vegetables; ubiquitin ligase; stress; growth and development