FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (23): 371-374.doi: 10.7506/spkx1002-6630-201023082

• Nutrition & Hygiene • Previous Articles     Next Articles

in vitro Anti-tumor Effect of Germanium-riched Barley Seedling

DU Rong1，WANG Xiao-jie1,*，XU Qing1，RUAN Xin2，LIU Xin-sheng3，QU Yan-qing3，
YANG Li-hong1，XIAO Yan-yan1   

  1. 1. College of Life Science, Ludong University, Yantai 264025, China；2. Yantai Entry and Exit Inspection and Quarantine Bureau,
    Yantai 264000, China；3. College Hospital, Ludong University, Yantai 264025,China
  • Received:2010-08-30 Online:2010-12-15 Published:2010-12-29
  • Contact: WANG Xiao-jie E-mail:wxj10304@126.com

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Abstract:

Objective: To investigate the anti-tumor effect of Germanium-enriched barley seedling (GEBS) in vivo and in vitro. Methods: The S-180 model mice were administered with GEBS at different dosages by gavage for 12 consecutive days. The effect of GEBS on tumor weight, thymus index and spleen index of mice was explored. Meanwhile, the inhibition effect of GEBS on the proliferation of mouse sarcoma cell S-180 and myeloma cell SP-2 was also evaluated by MTT assay. Results: GEBS with high dosage could obviously suppress the growth of S-180 sarcoma in mice with an inhibition rate of 68.52% (P＜0.05) and increase the thymus index and spleen index (P＜0.05). Moreover, GEBS could obviously inhibit the growth of mouse sarcoma cell S-180 and myeloma cell SP-2 in vitro in a positive dosage-dependent manner. Conclusion: GEBS can obviously inhibit the growth of tumor in vivo and in vitro.

Key words: germanium-rich barley seedling, sarcoma S-180, myeloma SP-2, mice

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