Abstract:

A compound Lithospermum antioxidant (FZK) was prepared using Lithospermum ethanol extract (Z), licorice ethanol extract (G), Sophora japonica extraction (H) from alkali extraction and acid precipitation, citric acid (N) and vitamin E (E) by the ratio of 10:5:5:2:1 (Z:G:H:N:E). The toxicity of FZK was evaluated by acute toxicity test, micronucleus test of bone marrow cells in mice, and chromosomal aberration test of bone marrow cells. Results indicated that the maximum tolerance dose of oral administration in mice was 16000 mg/kg body weight. According to acute toxicity classification criteria, FZK is non-toxic. However, FZK didn t exhibit a role in improving micronucleus rate of polychromatic erythrocyte and the mutagenicity in mice at the dose of less than 8000 mg/kg body weight.

Key words: Lithospermum, licorice, bud of Sophora japonica, toxicology, safe