FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (11): 214-220.doi: 10.7506/spkx1002-6630-201011046

• Nutrition & Hygiene • Previous Articles     Next Articles

Effect of Creatine Pyruvate on Carcass Characteristics and Amino Acid Compositions in Rats

KONG Yi-li,LIU Yi,ZHANG Yuan-shu,SU Xiao-qian,MA Hai-tian*,ZOU Si-xiang   

  1. Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University,
    Nanjing 210095, China
  • Received:2009-09-21 Revised:2010-03-01 Online:2010-06-01 Published:2010-12-29
  • Contact: MA Hai-tian E-mail:mahaitian@njau.edu.cn

Abstract:

In order to investigate the effect of creatine pyruvate (CrPyr) on metabolic direction of nutritive substances, rats were administered CrPyr to explore carcass characteristics and amino acid compositions in serum and tissues. Forty healthy male SD rats were randomly divided into four groups, which were administered CrPyr at the dosages of 0, 750, 1500 mg/(kg bw·d) and 3000 mg/(kg bw·d), respectively. On the 49th day of the experiments, all rats were scarified after 12 h fasting. The content of amino acids in serum and tissues were determined by reversed-phase high performance liquid chromatography (RP-HPLC). Results showed that relative weight of leg muscle in CrPyr-treated groups was significantly increased (P< 0.05) compared with the control group. Similarly, CrPyr-treated groups exhibited a significant increase in the content of glucogenic amino acid in serum and muscle. However, no obvious difference in amino acid composition in liver was observed. These investigations suggested that CrPyr could improve protein synthesis by elevating the concentration of glucogenic amino acid in serum and muscle of rats.

Key words: rats, creatine pyruvate, amino acid

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