乳清蛋白肽对幼年大鼠生长发育的影响

doi:10.7506/spkx1002-6630-201001053

食品科学 ›› 2010, Vol. 31 ›› Issue (1): 227-231.doi: 10.7506/spkx1002-6630-201001053

乳清蛋白肽对幼年大鼠生长发育的影响

徐琳琳，马奕，许雅君，李勇

北京大学公共卫生学院营养与食品卫生学系

收稿日期:2009-02-27 出版日期:2010-01-01 发布日期:2014-05-19
通讯作者: 许雅君 E-mail:xuyajun@bjmu.edu.cn

Effect of Whey Protein Peptides on Growth and Development of Young Rats

XU Lin-lin，MA Yi，XU Ya-jun，LI Yong

Department of Nutrition and Food Hygiene , School of Public Health, Peking University, Beijing 100191, China

Received:2009-02-27 Online:2010-01-01 Published:2014-05-19
Contact: XU Ya-jun， E-mail:xuyajun@bjmu.edu.cn

摘要/Abstract

摘要：

目的：探讨乳清蛋白肽对幼年大鼠体格、长骨发育及血液参数的影响。方法：40 只雄性断乳SD 大鼠随机分为1 个阴性对照组和低(0.225%)、中(0.45%)、高(1.35%)3 个乳清蛋白肽干预组，每组10 只动物。连续喂养42d，期间每周测量体重和身长一次，计算食物利用率，实验结束时对每只大鼠进行血液常规和生化标检测，并测定股骨长度、直径、骨矿物质含量和密度。结果：中、高剂量乳清蛋白肽干预组大鼠体重及食物利用率较对照显著增高；高剂量组大鼠股骨近端骨密度及矿物质含量较对照显著增加；乳清蛋白肽干预组大鼠股骨干重、长度和直径较对照有增加趋势，但尚未见统计学差异；中、高剂量组大鼠血肌酐和血尿酸含量较对照组显著降低。结论：一定剂量的乳清蛋白肽能够促进幼年大鼠体格发育和增加长骨矿物质密度。

关键词: 乳清蛋白肽, 生长发育, 骨矿物质密度

Abstract:

Objective: To investigate the effect of low-molecular-weight whey protein peptides (WPP) on physical development, bone growth and blood parameters in young rats. Methods: Forty male SD rats were randomly divided into 4 groups of 10 rats each, designated as control group, groups with WPP intervention at low, middle and high doses, which were 0.225%, 0.45 % and 1.35 % WPP, respectively. All rats were subjected to feeding for 42 consecutive days. Body weight and length of each rat were measured once a week. Blood parameters, femur length and diameter, bone mineral content and bone density of each rat were analyzed at the end of experimental period. Results: WPP intervention at the dose of 0.45 % and 1.35 % resulted in an obvious increase in body weight, femur length, and food utilization rate of rats. Compared to the control group, the bone mineral density and mineral content of proximal femur in rats treated with 1.35 % WPP exhibited a significant increase although no significant impact on femur dry weight, length and diameter. Moreover, the levels of serum creatinine and uric acid in rats treated with 0.45 % and 1.35 % WPP were significantly decreased. Conclusion: WPP could promote growth and development of young rats, and enhance their bone mineral density.

Key words: whey protein peptides, growth and development, bone mineral density

中图分类号:

徐琳琳，马奕，许雅君，李勇. 乳清蛋白肽对幼年大鼠生长发育的影响[J]. 食品科学, 2010, 31(1): 227-231.

XU Lin-lin，MA Yi，XU Ya-jun，LI Yong. Effect of Whey Protein Peptides on Growth and Development of Young Rats[J]. FOOD SCIENCE, 2010, 31(1): 227-231.

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乳清蛋白肽对幼年大鼠生长发育的影响

Effect of Whey Protein Peptides on Growth and Development of Young Rats

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