关键词: 苹果膳食纤维, 小鼠, 血糖, 血脂

Abstract: In order to explore the effect of apple dietary fiber on blood glucose level in diabetic mice and blood lipid level in hyperlipidic mice, apple dietary fiber at 4%, 2% and 1% doses was added to a basal diet for ICR mice with diabetes and to a high-fat diet for normal ICR mice, respectively. In the hypoglycemic evaluation of apple dietary fiber, ICR mice with diabetes fed the basal diet without added apple dietary fiber served as a model control group. The normal control and model control groups used for the hypolipidemic evaluation were given the basal diet and high-fat diet, respectively. Blood glucose and blood lipid of all the mice were determined at the end of the hypoglycemic and hypolipidemic treatments. The results indicated that the blood glucose level of the diabetic mice administered with apple dietary fiber at low doses did not exhibit an obvious decrease; however, the blood glucose was obviously inhibited in the mice administered with apple dietary fiber at the dose of 4% compared to the model control group. Meanwhile, apple dietary fiber at the dose of 4% also could effectively decrease serum total cholesterol (TC) and atherosclerosis index (AI) although it is difficult to decrease to normal level. On the other hand, apple dietary fiber at the high dose could result in the reduction of serum triglyceride to the normal level. Conclusion: Apple dietary fiber at the high dose level of 4% can reduce the blood glucose and blood lipid, but it does not reveal an obvious effect at the low dose level.

Key words: apple dietary fiber, mice, blood glucose, blood lipid