c9t11- 和t10c12- 共轭亚油酸抗癌和影响脂质代谢的异同

doi:10.7506/spkx1002-6630-201013068

食品科学 ›› 2010, Vol. 31 ›› Issue (13): 297-301.doi: 10.7506/spkx1002-6630-201013068

c9t11- 和t10c12- 共轭亚油酸抗癌和影响脂质代谢的异同

刘佩¹，沈生荣¹，阮辉¹，刘琦²，何国庆^1,*

1.浙江大学生物系统工程与食品科学学院
2.胶南市科学技术局

收稿日期:2009-12-10 出版日期:2010-07-01 发布日期:2010-12-29
通讯作者: 何国庆1,* E-mail:gqhe@zju.edu.cn
基金资助:
国家“863”计划重点项目(2007AA100402)

c9t11- and t10c12-CLA: Difference in Biological Functions and Mechanisms

LIU Pei1，SHEN Sheng-rong1，RUAN Hui1，LIU Qi2，HE Guo-qing1,*

1. School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, China；
2. Jiaonan Science and Technology Bureau, Qingdao 266400, China

Received:2009-12-10 Online:2010-07-01 Published:2010-12-29
Contact: HE Guo-qing1,* E-mail:gqhe@zju.edu.cn

摘要/Abstract

摘要：

共轭亚油酸(CLA)是一组位置和构象异构体的总称，异构体c9t11-CLA 和t10c12-CLA 或二者的协同作用赋予了CLA 的许多生理功能，比如抗癌、降低体脂含量、预防糖尿病的发生、降低血脂抑制动脉粥样硬化等；异构体c9t11-CLA 和t10c12-CLA 在结构及来源上存在一定差别——由于双键位置的不同，t10c12-CLA 异构体比c9t11-CLA 异构体更容易氧化；而在生理功能上二者也有差异—— c9t11-CLA 异构体的主要作用是抗癌，而 t10c12-CLA 则是降低体脂、血脂等，大量单一异构体的体外实验研究表明二者在抗癌及脂肪代谢的调节上作用机制也不尽相同。

关键词: c9t11- 共轭亚油酸, t10c12- 共轭亚油酸, 抗癌作用, 机体构成, 脂肪代谢

Abstract:

Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers, and numerous biological functions such as anticancer, reduction of body fat content, diabetes prevention, lower blood lipids and inhibition of arteriosclerosis are due to individual or synergistic action of most isomers including c9t11- and t10c12-CLA. Because of different positions of double bounds between c9t11- and t10c12-CLA isomers, high oxidization possibility of c9t11-CLA isomer was observed. Therefore, c9t11-CLA isomer exhibited a major responsibility for anticarcinogenic effect, whereas, t10c12-CLA isomer exhibited stronger reduction effect on body fat and blood lipids. Increasing studies suggested that the mechanisms of both isomers on cancer and fat metabolism were different.

Key words: c9t11-CLA, t10c12-CLA, anticancer, body composition, fat metabolism

中图分类号:

TS218

刘佩1，沈生荣1，阮辉1，刘琦2，何国庆1,*. c9t11- 和t10c12- 共轭亚油酸抗癌和影响脂质代谢的异同[J]. 食品科学, 2010, 31(13): 297-301.

LIU Pei1，SHEN Sheng-rong1，RUAN Hui1，LIU Qi2，HE Guo-qing1,*. c9t11- and t10c12-CLA: Difference in Biological Functions and Mechanisms[J]. FOOD SCIENCE, 2010, 31(13): 297-301.

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c9t11- 和t10c12- 共轭亚油酸抗癌和影响脂质代谢的异同

c9t11- and t10c12-CLA: Difference in Biological Functions and Mechanisms

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