食品科学 ›› 2010, Vol. 31 ›› Issue (9): 255-258.doi: 10.7506/spkx1002-6630-201009057

• 营养卫生 • 上一篇    下一篇

红菇多糖的提取及其降血糖、血脂作用研究

陈旭健1,张原琪2   

  1. 1.玉林师范学院 2.玉林市第二人民医院
  • 收稿日期:2009-09-11 出版日期:2010-05-01 发布日期:2010-12-29
  • 通讯作者: 陈旭健 E-mail:ylcxj123@tom.com
  • 基金资助:

    广西自然科学基金项目(0728250)

Polysaccharide Extract from Russula and Its Role of Lowering Blood Glucose and Lipid

CHEN Xu-jian1,ZHANG Yuan-qi2   

  1. 1. Yulin Normal College, Yulin 537000, China;2. The Second People s Hospital of Yulin, Yulin 537000, China
  • Received:2009-09-11 Online:2010-05-01 Published:2010-12-29
  • Contact: CHEN Xu-jian E-mail:ylcxj123@tom.com

摘要:

目的:探讨红菇多糖的提取纯化及其降血糖、血脂作用。方法:用热水浸提法从红菇子实体提取粗多糖,并进行离子交换层析及凝胶层析纯化。通过注射四氧嘧啶和饲喂高脂饲料建立糖尿病及高脂血症小鼠模型,然后用红菇多糖给药处理,检测血糖、血脂各项指标的变化情况。结果:与对照组相比,红菇多糖给药组的葡萄糖(GLU)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)指标极显著下降(P < 0.01),高密度脂蛋白胆固醇(HDL-C)指标极显著上升(P < 0.01),并且高剂量组比低剂量组效果更好。结论:红菇多糖有降血糖、血脂作用。

关键词: 红菇多糖, 血糖, 血脂

Abstract:

Objective: To explore the purification of Russula polysaccharide and its role of lowering glucose and lipid. Methods: Crude polysaccharide was extracted from Russula fruit bodies through soaking extraction method in hot water and purified through ion-exchange chromatography and gel chromatography. The mice model with diabetes and hyperlipidemia was established through the injection of alloxan and the feeding of high-fat food. The model mice were administrated with Russula polysaccharide. Blood glucose and blood lipid in model mice with diabetes and hyperlipidemia were evaluated. Results: GLU, TC, TG and LDL-C exhibited a significant decrease (P <0.01) in mice with the administration of Russula polysaccharide in a dose-dependent manner. Conclusion: Russula polysaccharide has excellent functions in lowering blood glucose and lipid levels.

Key words: Russula polysaccharide, blood glucose, blood lipid

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