毛竹叶多糖对高脂血症小鼠的降脂利肝作用

doi:10.7506/spkx1002-6630-201009058

食品科学 ›› 2010, Vol. 31 ›› Issue (9): 259-262.doi: 10.7506/spkx1002-6630-201009058

毛竹叶多糖对高脂血症小鼠的降脂利肝作用

丁红秀^{1 , 2}，高荫榆^{2 ,*} ，晁红娟²，夏冬华²

1.江西师范大学生命科学学院 2. 南昌大学食品科学与技术国家重点实验室

收稿日期:2009-08-05 出版日期:2010-05-01 发布日期:2010-12-29
通讯作者: 丁红秀 E-mail:sd_dinghx@sina.com
基金资助:
教育部“长江学者和创新团队发展计划”项目(IRT0540)

Effect of Polysaccharide from Moso Bamboo Leaves on Blood Lipid of Mice with Hyperlipemia

DING Hong-xiu1,2，GAO Yin-yu2,*，CHAO Hong-juan2，XIA Dong-hua2

1. College of Life Science, Jiangxi Normal University, Nanchang 330022, China；2. State Key Laboratory of Food Science and
Technology, Nanchang University, Nanchang 330047, China

Received:2009-08-05 Online:2010-05-01 Published:2010-12-29
Contact: DING Hong-xiu E-mail:sd_dinghx@sina.com

摘要/Abstract

摘要：

研究毛竹叶多糖的降血脂、肝脂及促进肝损伤修复的作用。以正常小鼠作空白对照，将高脂血症脂肪肝模型小鼠分为高脂模型组、毛竹叶多糖低、中、高剂量组和血脂康阳性药物对照组，进行不同灌胃处理，测定小鼠血脂、血清谷丙转氨酶(ALT)、肝粗脂肪含量、肝指数及肝组织细胞形态变化。结果表明：毛竹叶多糖可显著降低小鼠血清总胆固醇(TCHO)、甘油三酯(TG)、低密度脂蛋白(LDL)；对血清高密度脂蛋白(HDL)影响不明显；可显著降低肝粗脂肪含量，改善小鼠的肝功能。

关键词: 毛竹叶多糖, 高血脂, 脂肪肝, 降血脂, 肝功能

Abstract:

In order to investigate the functions of polysaccharide from moso bamboo leaves (PMBL) for decreasing blood lipid and liver lipid and promoting the recovery of damaged liver, the mice model with hyperlipidemia was established through the feeding of high-fat food to evaluate the effect of PMBL on lipid metabolism of mice. Totally 50 mice were divided into 5 groups designated as hyperlipidemia model group, PMBL groups at low, middle and high dosages, and positive control group. Blood lipid, serum ALT, crude fat content in liver, liver index and morphological change of liver tissues were evaluated. Results indicated PMBL could result in a significant reduction of total cholesterol, triglyceride and low-density lipoprotein in serum; however, no significant effect on high-density lipoprotein was observed. In addition, PMBL could decrease crude fat content in liver, and improve the hepatic function of mice. In a word, PMBL exhibited anti-lipidemic activity and lipid-reducing effect in liver to enhance the repairing of damaged liver in mice with hyperlipidemia at the condition of optimal dosage.

Key words: polysaccharide from moso bamboo leaves, hyperlipemia, fatty liver, blood-lipid lowering, hepatic function

中图分类号:

Q71
O629.12

丁红秀1,2，高荫榆2,*,晁红娟2，夏冬华2. 毛竹叶多糖对高脂血症小鼠的降脂利肝作用[J]. 食品科学, 2010, 31(9): 259-262.

DING Hong-xiu1,2，GAO Yin-yu2,*，CHAO Hong-juan2，XIA Dong-hua2. Effect of Polysaccharide from Moso Bamboo Leaves on Blood Lipid of Mice with Hyperlipemia[J]. FOOD SCIENCE, 2010, 31(9): 259-262.

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毛竹叶多糖对高脂血症小鼠的降脂利肝作用

Effect of Polysaccharide from Moso Bamboo Leaves on Blood Lipid of Mice with Hyperlipemia

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