Effect of Sargassum fusiforme Polysaccharides with Different Relative Molecular Weights on Learning and Memory Ability in Mice Model of Memory Impairment Induced by Raceanisodamine

doi:10.7506/spkx1002-6630-201801033

FOOD SCIENCE ›› 2018, Vol. 39 ›› Issue (1): 221-225.doi: 10.7506/spkx1002-6630-201801033

• Nutrition & Hygiene • Previous Articles Next Articles

Effect of Sargassum fusiforme Polysaccharides with Different Relative Molecular Weights on Learning and Memory Ability in Mice Model of Memory Impairment Induced by Raceanisodamine

LIU Hongchao1, YING Miaomiao2,*, SHI Wenzheng1,*, XIE Jun1, YANG Jingya1, WANG Zhihe1

1. Shanghai Engineering Research Center of Aquatic Product Processing and Preservation,College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; 2. Wenzhou Vocational College of Science and Technology, Wenzhou 325000, China

Online:2018-01-15 Published:2018-01-05

Abstract

Abstract: The effects of Sargassum fusiforme polysaccharide (SFPS) and its fractions separated by ultrafiltration (SFPSⅤ and SFPSⅣ) on the learning and memory ability in mice were investigated and the underlying mechanisms were explored. A mouse model of memory impairment was established by intraperitoneal injection of racemic anisodamine, and Morris water maze place navigation test was used to evaluate the learning and memory ability. The results showed SFPS could improve the learning and memory ability in mice with memory impairment. Compared with the model group, medium-dose SFPSⅤ significantly shortened the mean escape latency and increased the number of crossing the platform (P < 0.05). SFPS with lower molecular weight was the most effective in improving the learning and memory ability among the polysaccharides tested and was superior to piracetam (P < 0.05). The underlying mechanism may be related to the antioxidant activity of SFPS. These findings may provide some useful guidance for the application of SFPS and the study of its activity.

Key words: Sargassum fusiforme polysaccharide, raceanisodamine, learning and memory, antioxidant capacity

CLC Number:

TS201.2

LIU Hongchao, YING Miaomiao, SHI Wenzheng, XIE Jun, YANG Jingya, WANG Zhihe. Effect of Sargassum fusiforme Polysaccharides with Different Relative Molecular Weights on Learning and Memory Ability in Mice Model of Memory Impairment Induced by Raceanisodamine[J]. FOOD SCIENCE, 2018, 39(1): 221-225.

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Effect of Sargassum fusiforme Polysaccharides with Different Relative Molecular Weights on Learning and Memory Ability in Mice Model of Memory Impairment Induced by Raceanisodamine

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