Abstract: Objective: To explore the anti-fatigue and anti-hypoxia effect of degreased peptides from Antarctic krill in mice. Methods: The mice were randomly divided into four groups including the control group administered with water and three experimental groups administered with degreased peptides from Antarctic krill at doses of 0.2, 1.0, 5.0 g/(kg·d) for 28 consecutive days, respectively. The swimming time and the contents of lactic acid (LA), blood urea nitrogen (BUN) and lactate dehydrogenase (LDH) in serum, liver glycogen, survival time and oxygen consumption in hypoxia tolerance test, survival time after sodium nitrite poisoning were determined. Results: The degreased peptides from Antarctic krill at high dose could improve the swimming time, serum LDH activity, lactate clearance rate and the content of liver glycogen and decrease BUN in serum. Meanwhile, these degreased peptides at high dose could also increase the survival time in both hypoxia tolerance test and sodium nitrite poisoning experiment. Conclusion: The degreased peptides from Antarctic krill can eliminate fatigue and increase anti-hypoxia capacity in vivo. These investigations will have a significant impact on human health care.

Key words: Antarctic krill, degreased peptides, anti-fatigue, anti-hypoxia, mice