Abstract: The synthesis of vitamin E acetate using SO42-/Tio2 solid super acid as a novel catalyst was investigated with respect to catalyst dose, molar ratio of acetic anhydride to vitamin E, reaction time and reaction temperature. Based on fuzzy mathematical modeling, the optimal synthesis conditions were determined to be temperature 40 ℃, reaction time 3 h, molar ratio of vitamin E to acetic anhydride 1:1.2, and catalyst dose 1.0 g. Under these conditions, the conversion rate of vitamin E was 96.6%. The product obtained was identified as vitamin E acetate by infrared spectrum (IR), elemental analysis and 1H NMR.

Key words: vitamin E acetate, spectroscopic analysis, characterization, solid super acid, fuzzy mathematics