Effect of Conjugated Linoleic Acid on Weight Loss of Obesity Mice

Abstract

Abstract: The effect of intragastric administration of conjugated linoleic acid (CLA) for 4 consecutive weeks on body weight, body fats, blood lipids and liver fatty acid synthase in animal models of dietary obesity created using Kunming mice. Meanwhile, the correlation between FAS and obesity was also explored. The results showed that Lee,s index, fat coefficient, serum total cholesterol (TC), serum total triglyceride (TG), serum low density lipoprotein cholesterol (LDL-C) and liver FAS in obese mice administered with CLA at the dosages investigated exhibited a significant difference from those in obese mouse models. Moreover, an obvious correlation between FAS and Lee,s index, fat coefficient or blood lipid was observed. Therefore, CLA has effective weight-lowering effect. Furthermore, the view that FAS is the potential target of obesity is further confirmed.

Key words: conjugated linoleic acid, mouse, weight loss, fatty acid synthase

CLC Number:

TS201.2

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