Abstract: The effect of feeding Douchi was evaluated on mouse thrombosis induced by subcutaneous injection with 10 mg/mL carrageenan at the back waist of mice. ICR mice were divided into three groups: Douchi treatment group (thrombosis model mice fed Douchi and normal saline extract from Douchi), model control group (thrombosis model mice fed full nutrition diet and distilled water) and normal control group (normal mice fed full nutrition diet and distilled water). The results showed that the mice in the Douchi treatment group exhibited an initial decrease and subsequent increase in body weight, a slight increase in prothrombin time (PT) and thrombin time (TT), and a reduction in plasma fibrinogen (FIB) during the experiment. The detection of D-dimer was positive after 10 days of feeding and PT and TT were notably prolonged (P < 0.05) in the mice fed for 15 days. However, PT and TT showed no significant difference between the model control group and normal control group. Therefore, Douchi can activate the function of fibrinolysis, inhibit the function of blood-clotting system, and prevent and treat thrombosis diseases.

Key words: Chinese Douchi, thrombosis model, length of infarcted regions, fibrinolytic activity, carrageenan