Purification of Glycyrrhizic Acid from Glycyrrhiza Using Macroporous Resin

doi:10.7506/spkx1002-6630-201306020

Abstract

Abstract: The purification of glycyrrhizic acid from glycyrrhiza using macroporous resin was study. Static absorption and desorption experiments were carried out to screen the optimal resin from macroporous resins DA201-C and AB-8. AB-8 was found to have better performance than DA201-C. In static adsorption and desorption experiments, the optimal purification conditions of glycyrrhizic acid by resin AB-8 were sample pH 6.0, 5.89 mg/mL sample concentration, and 50% ethanol as the desorption solvent. In addition, the purity of purified glycyrrhizic acid was determined by HPLC to be 52.3%, and was increased to 76.0% after recrystallization.

Key words: glycyrrhizic acid, macroporous resin, high performance liquid chromatography (HPLC), ultraviolet spectrophotometry

CLC Number:

TS201.2

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