Abstract: Aflatoxin B1 (AFB1) is a threat to human and animal health. AFB1 detoxification by microorganisms has become the focus of current research due to its safety and high efficiency. However, there are still bottlenecks such as long action period, unstable detoxification function, and difficulties in separation and purification. Therefore, efficient removal of AFB1 is great significance to ensure food safety. This paper summarizes the molecular mechanisms of AFB1 toxicity, including the mechanisms of action at the gene and protein levels and the toxicity sites. It focuses on recent progress in the microbial detoxification of AFB1 by adsorption and degradation, including bacteria, fungi and their metabolite, as well as the discovery and mechanisms of action of detoxification enzymes. In addition, the prospects of AFB1 detoxification technology with high efficiency and without pollution are also highlighted.

Key words: aflatoxin B1, molecular toxicity mechanism, microbial detoxification, detoxification mechanism