食品科学 ›› 2009, Vol. 30 ›› Issue (23 ): 419-421.doi: 10.7506/spkx1002-6300-200923094

• 营养卫生 • 上一篇    下一篇

蚕蛹蛋白多肽对小鼠免疫调节作用的研究

戚颖欣1,孟 军2,曹柏营1,费保亮1,闻其龙1   

  1. 1.吉林工程技术师范学院食品工程学院 2.吉林省通化市食品药品检验所
  • 收稿日期:2009-08-24 出版日期:2009-12-01 发布日期:2010-12-29
  • 通讯作者: 戚颖欣 E-mail:qyxlclhb@163.com
  • 基金资助:

    吉林省教育厅计划项目(吉教科合字第(2009233)号)

Immunoregulation Functions of Pupa Polypeptides in Mice

QI Ying-xin1,MENG Jun2,CAO Bai-ying1,FEI Bao-liang1,WEN Qi-long1   

  1. 1. College of Food Engineering, Jilin Teachers’Institute of Engineering and Technology, Changchun 130052, China;
    2. Institute for Food and Drug Control of Tonghua City of Jilin Province, Tonghua 134000, China
  • Received:2009-08-24 Online:2009-12-01 Published:2010-12-29
  • Contact: QI Ying-xin E-mail:qyxlclhb@163.com

摘要:

实验观察蚕蛹蛋白多肽对小鼠的免疫调节作用。实验将蚕蛹蛋白多肽分为高、中、低剂量组,分别为5.0、1.7、0.6g/kg bw·d 喂饲小鼠40d,观察小鼠免疫器官指数变化、迟发型变态反应(DTH)、抗体生成细胞数和碳廓清能力等4 个实验项目。实验结果表明:与阴性对照组比较,蚕蛹蛋白多肽能显著增加小鼠胸腺指数,增加小鼠足跖肿胀度,增加小鼠抗体细胞生成数量,增加单核- 巨噬细胞吞噬能力。说明蚕蛹蛋白多肽具有明显的免疫调节作用。

关键词: 蚕蛹蛋白, 多肽, 免疫调节

Abstract:

In order to investigate immunoregulation functions of pupa polypeptides, mice were randomly divided 3 groups and conducted to oral administration of pupa polypeptides at the doses of 5.0, 1.7 g/kg·d and 0.6 g/kg·d for 40 days, respectively. Changes in immune organ index, delayed-type hypersensitivity (DTH), number of antibody-producing cells and carbon clearance capability were examined to evaluate immune functions. Results indicated that pupa polypeptides could significantly improve thymus index, promote plantar swelling, increase the generation of antibody-producing cells and enhance capability of monocyte-macrophage phagocytosis. Therefore, pupa polypeptides exhibited a significant effect on improvement of immune functions in mice.

Key words: pupa protein, polypeptide, immunoregulation effect

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