食品科学
• 营养卫生 • 上一篇 下一篇
曾 东1,2,刘玉芝1,唐 超1,全弘扬1,张海明1,倪学勤1,2,*
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国家级大学生创新性实验计划项目(101062619);教育部留学回国人员科研启动资金项目(0835-1); 四川省学术带头人培养基金项目
ZENG Dong1,2,LIU Yu-zhi1,TANG Chao1,QUAN Hong-yang1,ZHANG Hai-ming1,NI Xue-qin1,2,*
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摘要:
对草芽孢杆菌HB-32分批发酵过程中菌体细胞生长、3-羟基丁酮的形成以及葡萄糖的消耗随发酵时间的变 化规律进行研究。基于Logistic方程和Luedeking-Piret方程,建立3-羟基丁酮分批发酵过程中细胞生长、产物合成以 及基质消耗随时间变化的数学模型。对动力学模型的拟合曲线进行分析,发现模型的计算值能与实验值较好地拟 合,拟合模型R2均大于0.98,表明建立的动力学模型能较好地反映3-羟基丁酮分批发酵过程。
关键词: 枯草芽孢杆菌, 高血脂, 脂质代谢, 激素敏感性脂肪酶
Abstract:
Objective: To explore the effect of Bacillus subtilis JS01 on lipid metabolism in hyperlipidemic mice. Methods: Ninety Kunmng mice were randomly divided into normal control group (Group Ⅰ), high-fat model group (Group Ⅱ) and highfat + Bacillus subtilis group (Group Ⅲ). Ten mice were selected from each group and killed on the 15th (D15), 30th (D30) and 45th (D45) days of the experiment, respectively. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in serum and hormone-sensitive lipase (HSL) activity level in liver were detected. Results: 1) At the three time points, serum TC, LDL-C, HDL-C and LDL-C/HDL-C ratio in Group Ⅱ were higher than that in Group Ⅰ (P < 0.05, P < 0.01). 2) At D15 and D30, serum TG in Group Ⅱ was higher than that in Group Ⅰ and Group Ⅲ. At D30 and D45, serum HDL-C in Group Ⅲ was higher than that in Group Ⅱ (P < 0.05). 3) At D45, liver HSL activity in Group Ⅲ was higher than that in Group Ⅰ and Group Ⅱ (P < 0.01). Conclusion: Bacillus subtilis JS01 has hypolipidemic effect to some extent by improving HDL-C in serum and HSL activity in liver, while reducing TG, TC and LDL-C in serum of hyperlipidemic mice.
Key words: Bacillus subtilis, hyperlipidemia, lipid metabolism, hormone-sensitive lipase
中图分类号:
R589.2
TS201.3
曾 东1,2,刘玉芝1,唐 超1,全弘扬1,张海明1,倪学勤1,2,*. 枯草芽孢杆菌JS01对高血脂小鼠脂质代谢的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201313055.
ZENG Dong1,2,LIU Yu-zhi1,TANG Chao1,QUAN Hong-yang1,ZHANG Hai-ming1,NI Xue-qin1,2,*. Effect of Bacillus subtilis JS01 on Lipid Metabolism in Hyperlipidemic Mice[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201313055.
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https://www.spkx.net.cn/CN/Y2013/V34/I13/262