食品科学 ›› 2021, Vol. 42 ›› Issue (5): 340-348.doi: 10.7506/spkx1002-6630-20200221-232

• 专题论述 • 上一篇    下一篇

降尿酸肽对高尿酸血症的作用及研究进展

骆贤亮,刘滔,钱忠英,冯凤琴   

  1. (浙江大学生物系统工程与食品科学学院,农业农村部农产品采后处理重点实验室,浙江省农产品加工技术研究重点实验室,浙江 杭州 310058)
  • 出版日期:2021-03-15 发布日期:2021-03-29
  • 基金资助:
    宁波市“科技创新2025”重大专项(2019B10060)

Recent Progress in Research on Hyperuricemia and Uric Acid-Lowering Peptides

LUO Xianliang, LIU Tao, QIAN Zhongying, FENG Fengqin   

  1. (Key Laboratory of Agro-products Postharvest Handling, Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agro-food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China)
  • Online:2021-03-15 Published:2021-03-29

摘要: 降尿酸肽是食物蛋白经酶解得到的具有降尿酸作用的肽类化合物。高尿酸血症会引发痛风、心血管疾病、肾病和糖尿病等一系列代谢综合征,严重威胁人类健康。而临床上,许多降尿酸药物具有毒副作用,因此,开发安全有效的降尿酸肽具有实际应用意义。本文从高尿酸血症的发病机理、常用的建模方法、降尿酸肽与黄嘌呤氧化酶结合的构效关系及其体内活性评价研究现状等方面进行概述,并对降尿酸肽未来研究方向作出展望,为降尿酸肽的进一步研究与开发提供一定的理论支持。

关键词: 降尿酸肽;高尿酸血症;动物模型;作用机理

Abstract: The enzymatic hydrolysis of food proteins can produce uric acid-lowering peptides. Hyperuricemia can cause a series of metabolic syndromes such as gout, cardiovascular disease, kidney disease and diabetes, seriously threatening human health. Numerous uric acid-lowering drugs have toxic and side effects clinically. Therefore, it is of practical significance to develop more safe and effective uric acid-lowering peptides. This article summarizes the pathogenesis of hyperuricemia, the methods commonly used to establish animal models of hyperuricemia, the structure-activity relationship between uric acid-lowering peptides and xanthine oxidase, and the current status of research on the in vivo activity of uric acid-lowering peptides. Finally, we conclude with an outlook on future research directions. This article aims to provide theoretical support for the development and research of uric acid-lowering peptides.

Key words: uric acid-lowering peptides; hyperuricemia; animal models; mechanism of action

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