食品科学 ›› 2022, Vol. 43 ›› Issue (17): 362-371.doi: 10.7506/spkx1002-6630-20220304-056

• 专题论述 • 上一篇    下一篇

食源性晚期糖基化终末产物检测技术研究进展

李华韬,张巧智,倪皓洁,王彦波,刘福奇,傅玲琳   

  1. (1.浙江工商大学食品与生物工程学院,浙江食品质量安全工程研究院,浙江 杭州 310018;2.浙江工商大学实验室与资产管理处,浙江 杭州 310018)
  • 出版日期:2022-09-15 发布日期:2022-09-28
  • 基金资助:
    “十三五”国家重点研发计划项目(2019YFC1605002);浙江省基础公益研究项目(LGN20G010001)

Recent Advances in Detection Technologies for Dietary Advanced Glycation End Products

LI Huatao, ZHANG Qiaozhi, NI Haojie, WANG Yanbo, LIU Fuqi, FU Linglin   

  1. (1. Zhejiang Research Institute of Food Quality and Safety Engineering, School of Food Science and Biological Engineering, Zhejiang Gongshang University, Hangzhou 310018, China; 2. Laboratory and Asset Management Department, Zhejiang Gongshang University, Hangzhou 310018, China)
  • Online:2022-09-15 Published:2022-09-28

摘要: 晚期糖基化终末产物(advanced glycation end products,AGEs)是还原糖与蛋白质自由氨基间发生美拉德反应形成的一类异质性共价化合物的总称。研究发现食源性AGEs摄入后会在体内蓄积并对机体健康产生有害影响,因此有必要开展食物中各类AGEs的检测分析研究。食品中的AGEs种类繁多、结构复杂,目前缺少通用的检测分析方法。因此,本文针对食源性AGEs的结构和类型、与人体健康的关系以及相关检测技术进行综述,重点介绍食源性AGEs的免疫分析和仪器分析方法,深入探讨各类技术的特点和优劣势,并对后续研究方向进行展望,以期为食源性AGEs检测技术的发展以及相关研究体系的形成提供参考和借鉴。

关键词: 食品加工;晚期糖基化终末产物;健康危害;检测技术

Abstract: Advanced glycation end products (AGEs) are a class of heterogeneous compounds formed by the Maillard reaction between reducing sugars and free amino groups of proteins. Studies have found that dietary AGEs can be accumulated in the body, causing hazardous effects on human health. Therefore it is necessary to carry out detection and analysis of typical AGEs in foods. Currently, due to the wide variety and complex structure of dietary AGEs, there is a lack of general analytical methods for their detection. Therefore, this paper presents a review of the structure and types of dietary AGEs, their relationship with human health, and their state-of-the-art detection technologies. A specific focus is put on the immunoassays and instrumental methods used for the detection of dietary AGEs as well as their characteristics, advantages, and disadvantages. Furthermore, this paper provides an outlook on the future research directions in this field. We expect that this review will provide references for the development of new methods for the detection of dietary AGEs and the establishment of related research systems.

Key words: food processing; advanced glycation end products; health hazards; detection technologies

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