关键词: 驼乳免疫球蛋白G；秀丽隐杆线虫；抗衰老

Abstract: Objective: To investigate the anti-aging effect of camel milk immunoglobulin G (IgG) at different concentrations (0.25, 0.5, 1, 2, and 4 mg/mL) on the model organism Caenorhabditis elegans. Methods: The anti-aging activity of camel milk IgG was evaluated by analyzing the lifespan, reproductive capacity, locomotory capacity, stress resistance, and lipofuscin level of C. elegans. Results: Compared with the control group, the concentration of IgG in camel milk was safe, which damaged neither the reproductive nor locomotory capacity of C. elegans. Feeding of camel milk IgG at concentrations of 1, 2, and 4 mg/mL significantly prolonged the average lifespan of C. elegans, and at 0.5 and 4 mg/mL significantly increased the swallowing frequency (P < 0.05). Feeding of camel milk IgG at 0.25, 0.5 and 1 mg/mL significantly improved the heat stress resistance, and significantly prolonged the average lifespan of C. elegans (P < 0.05). Feeding of camel milk IgG at 1 and 4 mg/mL significantly increased the oxidative stress resistance of C. elegans (P < 0.05), and lipofuscin deposition was significantly decreased after 14-day feeding of camel milk IgG at 0.5 and 2 mg/mL (P < 0.05). Conclusion: Feeding a certain concentration of camel milk IgG has an anti-aging effect on C. elegans.

Key words: camel milk immunoglobulin G; Caenorhabditis elegans; anti-aging