食品科学 ›› 2006, Vol. 27 ›› Issue (7): 233-235.

• 营养卫生 • 上一篇    下一篇

菱角提取物对荷瘤小鼠免疫功能的影响

  牛凤兰, 董威严,  乔凤娟   

  1. 吉林大学公共卫生学院
  • 出版日期:2006-07-15 发布日期:2011-09-29

Effects of Trapa manshurica Extract on Immune Function in Tumor-bearing Mice

   Niu-Feng-Lan, DONG  Wei-Yan,   Qiao-Feng-Juan   

  1. School of Public Health, Jilin University, Changchun 130021, China
  • Online:2006-07-15 Published:2011-09-29

摘要: 目的:研究菱角(Trapamanshurica)提取物对荷瘤小鼠免疫功能的影响。方法:采用菱角提取物对肝癌腹水细胞H22进行体内实验,观察菱角提取物对荷瘤小鼠生长的影响及小鼠体重的变化;采用MTT法测定淋巴细胞增殖率;将小鼠灌胃给菱角提取物,给药的第4d每只小鼠腹腔注射5%(V/V)鸡红细胞悬液(CRBC),在油镜下观察巨噬细胞吞噬鸡红细胞的情况,计算吞噬率和吞噬指数。结果:体内抗肿瘤作用显示,菱角提取物在26.25g/kg时对肿瘤的抑制率为47%;菱角提取物对荷瘤小鼠脾淋巴细胞的增殖率为98.5%,显著高于阴性对照组;菱角提取物能增强小鼠腹腔巨噬细胞吞噬功能。结论:菱角能增强机体免疫功能。

关键词: 菱角, 免疫功能

Abstract:  Objective: To study the effects of Trapa manshurica extract on immune function in tumor-bearing mice. Methods: MTT assay was used to determine the multiplication rate of lymphocytes; Trapa manshurica extract was administrated into mice by lavage. Four days after administration, each mouse was given 5% CRBC with intraperitoneal injection. The phagocytosis of lymphocytes was observed by oil immersion. The phagocytic rate and phagocytic index were calculated. Results: the multipli- cation rate of lymphocytes in tumor-bearing mice treated with Trapa manshurica extract is 98.5%, significantly higher than thatin control group. Trapa manshurica extract enhances the phagocytic function of macrophages in mice. Conclusion: Trapa manshurica extract can enhance the immune function.

Key words:  , Trapa manshurica; immune function;